Application Studies
Explore studies, papers, and posters showcasing BioThrust technologies across different cell types and applications.
Cell Types
The ComfyCell enables superior yield and controllable EV quality
Future-proof your early stage EV research
We achieved a yield of up to 9x10^9 particles per mL, outperforming a static control ~5-fold. Secreted from bm-MSCs at up to 130k cells per mL.
Researchers at RWTH Aachen confirmed simple scale up & superior EV production with THP-1 cells compared to 2D.
The ComfyCell Incu significantly outperforms a 2D control and produces therapeutically active CD63 expressing EV particles. Secreted from uc-MSCs.
Achieve up to 44 million iPSCs per mL at large scale
Other bioreactors are limited by their oxygen transfer rate - BioThrust solved this bottleneck
Fed-batch iPSC experiments have proven that oxygen limitations are no longer a factor and media is now the key to yield increase.
We reached over 44 million cells per mL in an iPSC expansion run using our in-situ perfusion system.
A 5-day iPSC expansion process with our 2L in-situ perfusion consumable yielded almost 11 million cells per mL.
Easily scale up your microcarrier-based process
Easily maximize your MSC yield in 3D culture
Reproducible expansion of uc-MSCs in our 300mL Incu. Fold expansion of 13.7 for 3.15E5 cells per mL.
High quality bm-MSC expansion in our 300mL Incu. Over 49 million total cells after 7 days.
Clonally expanded & immortalized MSCs (expressing dtomato) achieving fold expansion >63 in our 2L vessel.
Maximize fold-expansion and final density with superb quality
Low shear stress and maximum gas transfer
Feeder-free expansion of iNK cells scaled up from 100mL to 2L by Catelent. 1000-fold expansion from thaw.
600-fold expansion of primary NKs with peak VCD of 3.6E6 NK cells per mL with quality superior to G-Rex.
First POC of T-Cell expansion in ComfyCell SUB. 60-fold expansion over 5 days. In-situ activation possible.
Reduce COGS by reducing downstream requirements
No anti-foam, no shear protectants
Foam-free CHO fed batch culture achieving +40% product conversion rate.
ATF-based high density CHO process yielding 30g protein titer per liter of working volume.
ATF-based high density HEK293 process reaching 93 million cells per mL, completely foam free.
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