November 7, 2024
BioThrust's 2L ComfyCell: Technical Data & Simulations
Bubble-free aeration and low-shear mixing in one scalable bioreactor component. BioThrust’s MemStir uses a membrane-based stirrer design to deliver adjustable oxygen transfer of up to 180 mmol L-1 h-1, near-homogeneous mixing, substantially reduced shear, and foam-free cultivation.
Introduction
3D production systems using prokaryotic- or eukaryotic cell lines, yeast and plant cells need optimal cultivation conditions especially adapted to their needs. Conventional stirred-tank bioreactors (STRs) are one of the most commonly used systems due to their versatile application, but struggle with high shearing, insufficient gas transfer and foam formation. To overcome these challenges, BioThrust developed a novel membrane stirrer (MemStir), which is used for both mixing and aeration of STRs.
Aeration is provided through bubble-free diffusion at the membrane–liquid interphase. The depletion of gas bubbles provides lower shear stress, maximal oxygen supply, fast gas-transfer rates and eliminates foam formation. In the following, technical properties and simulated performance of the MemStir are displayed.
Key Takeaways
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