Introducing ComfyCell
The all-in-one solution for scalable & controllable cell therapy manufacturing, consisting of a proprietary bionic bioreactor vessel package & compatible controller unit.
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Our Technical Breakthrough
The Incu is an easy to use, incubator based bioreactor ideally suited for early stage cell therapy development. With 300mL working volume its the logical step towards efficient CGT production.
The Benchtop holds world records for 3D iPSC density and other cell-related yields. It is our most flexible bioreactor to optimize your process from 300mL to 10L working volume at maximum efficiency.
BioThrust ComfyCell vs. Other Bioreactors
Homogeneous: CFD optimized laminar flow prevents all dead zones in the bioreactor and ensures cells experience gentle growth conditions.
Homogeneous: Gentle fluid flow throughout the vessel means cells experience similiar growth conditions.
Heterogeneous: High risk of dead zones and unequal flow mean cells will experience varying culture conditions.
Static: No hydrodynamic movement to support the cell culture. Limits scalability and nutrient exchange.
Linear: Scalable from 300mL to 200L thanks to similar vessel geometry and identical, highly efficient membrane-based gas transfer mechanism.
Complex: Only efficiently scalable from 80mL to 3L. Afterwards, very low gas transfer severely limits cell density and workarounds are needed.
Complex: Efficient scalability stops once bubble aeration (sparging) is needed - usually between 2L and 10L.
Impossible: Flasks need to be scaled out and can't be scaled up, leading to major workload and quality concerns.
Flexible: Either consistently low or consistently high, depending on what is needed for your process.
Low: Only supports consistently low shear stress environments.
Complex: Sparging creates inconsistent (i.e. harmful) high shear stress !
Static: No shear force due to 2D cell culture environment. Severely limits process intensity.
Very high: Up to 10x the gas transfer rate (O2 in & CO2 out) at low shear force. Membrane aeration avoids all bubbles and foam formation regardless of bioreactor volume or process intensity.
Very low: Small headspace area to vessel volume leads to minimal gas transfer. Problematic for efficient scale up.
Variable: Headspace aeration limits gas transfer, sparging causes foam & damaging shear forces. Therefore, complex and high risk trade-off to achieve meaningful process scale.
Low: Static 2D culture is limited in gas transfer but easy to implement.
Very Flexible: Can leverage in-situ perfusion, dip tubes, ATF, TFF, and more. Even combinations of several technologies are possible.
Limited: Perfusion is available but oxygen supply generally limits cell culture before nutrient supply.
Flexible: Can leverage dip tubes, ATF, TFF, and other perfusion technologies.
Limited: Specialized solutions exist but regular flasks have limited nutrient supply.
ComfyCell Product Catalogue
General
| Product Group | Product Type | Product Name |
|---|---|---|
| Benchtop Bioreactors | Controller | BioThrust Controller |
| Reusable Glass Vessel | BioThrust 2L Vessel | |
| BioThrust 10L Vessel | ||
| Single-Use Vessel | BioThrust 0.3L Vessel | |
| BioThrust 0.3L Perfusion Vessel | ||
| BioThrust 2L Vessel | ||
| BioThrust 2L Perfusion Vessel | ||
| BioThrust 12L Vessel (Q4 2026) | ||
| BioThrust 60L Vessel (2027) | ||
| BioThrust 200L Vessel (2028) | ||
| Bioreactor for Incubator | Base Unit | BioThrust Incu Base Unit |
| Single-Use Vessel | BioThrust Incu 0.3L Vessel |
ComfyCell Features
Maximum Cell Yield
Low Shear Forces
Low shear forces of integrated Membrane Stirrer both decrease cell destruction as well as increase growth and differentiation speed during cultivation.
Bubble-free Aeration
Bubble-free aeration inhibits the formation of foam. The absence of foam increases working volume & significantly eases the handling of the culture.
Unsurpassed Gas Transfer
Unsurpassed gas transfer efficiency of the Membrane Stirrer (up to 100%) enables higher cell densities that can reduce process duration & media consumption.
Application Agnostic
Slow Rotation Speed
Slow rotation speeds gently hold microcarriers & cell agglomerates of at least 3mm diameter in suspension.
Flexible Working Volume
Flexible working volumes & cell retention filter enable fed-batch & perfusion processes.
Real Scalability
Consistent Mixing Condition
Consistent mixing conditions in scale-up from 300 mL to 200 L due to geometric dimensioning of the vessel & Membrane Stirrer.
Stable Gas Transfer
Stable gas transfer rates across all sizes from 300 mL to 200 L due to proportional growing membrane surface area.
All for Quality & Control
Precise Shear Forces
Precisely controllable shear forces, independent of gas transfer rates.
Continuous CO2 Stripping
Continuous CO2-stripping to achieve unseen product quality due to no CO2 accumulations.
In-Process Control
In-process control for precise & cell-specific management of cultivation parameters.
Use Cases
Whether you want to upgrade your established processes or move into 3D cultivation, our wide range of offerings can support you!
Buy or rent our 300 mL to 2 L bioreactor systems to upgrade your processes or get started with 3D cell cultivation.
Apply our 2L to 60L bioreactor systems to support clinical trials of various sizes efficiently and ensure commercial viability.
Scale up therapies to industrial sizes with our technically verified 60L to 200L bioreactor systems.
Latest Publications
Experience ComfyCell for yourself.
Convince yourself of the new generation of bioreactors - short delivery times, attractive financing models, and process experts by your side make getting started as easy as possible for you.
