Introducing ComfyCell

The all-in-one solution for scalable & controllable cell therapy manufacturing, consisting of a proprietary bionic bioreactor vessel package & compatible controller unit.

A New Breakthrough

Our Technical Breakthrough

Our Technology

A 3D render image of 2L single use bioractor

Single Use Bioreactor

Closed-system Single-Use vessel in 300 mL to 10 L
In-process control with temperature, DO & pH sensors
Integrated BioThrust Membrane Stirrer

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Reusable Bioreactor

Autoclavable glass vessel in 250 mL to 10 L
In-process control with temperature, DO & pH sensors
Replaceable BioThrust Membrane Stirrer

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Bioreactor Controller

Modern touchscreen interface for process control & monitoring
Configurable process profiles
Small footprint
Four mass flow controllers & four fast-load pumps

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Incubator Bioreactor

Single-Use vessel in 300 mL
User friendly interface to control agitation & aeration
Incubator compatible
Integrated active pump for BioThrust Membrane Stirrer

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BioThrust ComfyCell vs. Other Bioreactors

ComfyCell

Homogeneous: CFD optimized laminar flow prevents all dead zones in the bioreactor and ensures cells experience gentle growth conditions.

Vertical Wheel

Homogeneous: Gentle fluid flow throughout the vessel means cells experience similiar growth conditions.

STR

Heterogeneous: High risk of dead zones and unequal flow mean cells will experience varying culture conditions.

Flask

Static: No hydrodynamic movement to support the cell culture. Limits scalability and nutrient exchange.

ComfyCell

Linear: Scalable from 300mL to 200L thanks to similar vessel geometry and identical, highly efficient membrane-based gas transfer mechanism.

Vertical Wheel

Complex: Only efficiently scalable from 80mL to 3L. Afterwards, very low gas transfer severely limits cell density and workarounds are needed.

STR

Complex: Efficient scalability stops once bubble aeration (sparging) is needed - usually between 2L and 10L.

Flask

Impossible: Flasks need to be scaled out and can't be scaled up, leading to major workload and quality concerns.

ComfyCell

Flexible: Either consistently low or consistently high, depending on what is needed for your process.

Vertical Wheel

Low: Only supports consistently low shear stress environments.

STR

Complex: Sparging creates inconsistent (i.e. harmful) high shear stress !

Flask

Static: No shear force due to 2D cell culture environment. Severely limits process intensity.

ComfyCell

Very high: Up to 10x the gas transfer rate (O2 in & CO2 out) at low shear force. Membrane aeration avoids all bubbles and foam formation regardless of bioreactor volume or process intensity.

Vertical Wheel

Very low: Small headspace area to vessel volume leads to minimal gas transfer. Problematic for efficient scale up.

STR

Variable: Headspace aeration limits gas transfer, sparging causes foam & damaging shear forces. Therefore, complex and high risk trade-off to achieve meaningful process scale.

Flask

Low: Static 2D culture is limited in gas transfer but easy to implement.

ComfyCell

Very Flexible: Can leverage in-situ perfusion, dip tubes, ATF, TFF, and more. Even combinations of several technologies are possible.

Vertical Wheel

Limited: Perfusion is available but oxygen supply generally limits cell culture before nutrient supply.

STR

Flexible: Can leverage dip tubes, ATF, TFF, and other perfusion technologies.

Flask

Limited: Specialized solutions exist but regular flasks have limited nutrient supply.

ComfyCell Product Catalogue

General

Product Group	Product Type	Product Name
Benchtop Bioreactors	Controller	BioThrust Controller
	Reusable Glass Vessel	BioThrust 2L Vessel
		BioThrust 10L Vessel
	Single-Use Vessel	BioThrust 0.3L Vessel
		BioThrust 0.3L Perfusion Vessel
		BioThrust 2L Vessel
		BioThrust 2L Perfusion Vessel
		BioThrust 12L Vessel (Q4 2026)
		BioThrust 60L Vessel (2027)
		BioThrust 200L Vessel (2028)
Bioreactor for Incubator	Base Unit	BioThrust Incu Base Unit
	Single-Use Vessel	BioThrust Incu 0.3L Vessel

Controls

Features	Header	Header	Header	Header
Width, Depth, Height	Cell	Cell	Cell	Cell
Width, Depth, Height	Cell	Cell	Cell	Cell
Width, Depth, Height	Cell	Cell	Cell	Cell
Width, Depth, Height	Cell	Cell	Cell	Cell
Width, Depth, Height	Cell	Cell	Cell	Cell

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ComfyCell Features

Maximum Cell Yield

Low Shear Forces

Low shear forces of integrated Membrane Stirrer both decrease cell destruction as well as increase growth and differentiation speed during cultivation.

Bubble-free Aeration

Bubble-free aeration inhibits the formation of foam. The absence of foam increases working volume & significantly eases the handling of the culture.

Unsurpassed Gas Transfer

Unsurpassed gas transfer efficiency of the Membrane Stirrer (up to 100%) enables higher cell densities that can reduce process duration & media consumption.

Application Agnostic

Slow Rotation Speed

Slow rotation speeds gently hold microcarriers & cell agglomerates of at least 3mm diameter in suspension.

Flexible Working Volume

Flexible working volumes & cell retention filter enable fed-batch & perfusion processes.

Real Scalability

Consistent Mixing Condition

Consistent mixing conditions in scale-up from 300 mL to 200 L due to geometric dimensioning of the vessel & Membrane Stirrer.

Stable Gas Transfer

Stable gas transfer rates across all sizes from 300 mL to 200 L due to proportional growing membrane surface area.

All for Quality & Control

Precise Shear Forces

Precisely controllable shear forces, independent of gas transfer rates.

Continuous CO2 Stripping

Continuous CO2-stripping to achieve unseen product quality due to no CO2 accumulations.

In-Process Control

In-process control for precise & cell-specific management of cultivation parameters.

A New Breakthrough

Use Cases

Whether you want to upgrade your established processes or move into 3D cultivation, our wide range of offerings can support you!

Process Development

Buy or rent our 300 mL to 2 L bioreactor systems to upgrade your processes or get started with 3D cell cultivation.

Clinical Trial Supply

Apply our 2L to 60L bioreactor systems to support clinical trials of various sizes efficiently and ensure commercial viability.

Commercialization

Scale up therapies to industrial sizes with our technically verified 60L to 200L bioreactor systems.

Latest Publications

See Application Studies

Paper

Homogeneous shear distribution improves NK-92 cell cytotoxicity in a clinically relevant 2 L membrane-stirred bioreactor

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Application Note

iPSC

Simple hiPSC Expansion as Spheroids with BioThrust's ComfyCell Incu

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Application Note

iPSC

Scalable hiPSC Expansion on Microcarriers with BioThrust’s ComfyCell

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Experience the Comfycell Yourself.

Convince yourself of the new generation of bioreactors - short delivery times, attractive financing models, and process experts by your side make getting started as easy as possible for you.

Introducing ComfyCell

Our Technical Breakthrough

Single Use Bioreactor

Reusable Bioreactor

Bioreactor Controller

Incubator Bioreactor

Our Technical Breakthrough

BioThrust ComfyCell vs. Other Bioreactors

ComfyCell Product Catalogue

General

Controls

ComfyCell Features

Maximum Cell Yield

Low Shear Forces

Bubble-free Aeration

Unsurpassed Gas Transfer

Application Agnostic

Slow Rotation Speed

Flexible Working Volume

Real Scalability

Consistent Mixing Condition

Stable Gas Transfer

All for Quality & Control

Precise Shear Forces

Continuous CO2 Stripping

In-Process Control

Use Cases

Latest Publications

Experience the Comfycell Yourself.

The solution for scalable and efficient cellular biomanufacturing.